Benzocaine-induced methemoglobinemia during transesophageal echocardiography.

Benzocaine-induced methemoglobinemia based on the Mayo Clinic experience from 28 478 transesophageal echocardiograms: incidence, outcomes, and predisposing factors.

BACKGROUND The potentially life-threatening condition of methemoglobinemia is characterized by cyanosis, low pulse oximetric readings, and normal arterial Po(2) values. Acquired methemoglobinemia has been linked to the use of the topical anesthetic benzocaine in endoscopic procedures, including transesophageal echocardiography (TEE). Yet, the incidence of benzocaine-induced methemoglobinemia wi...

Risk of acquired methemoglobinemia with different topical anesthetics during endoscopic procedures

INTRODUCTION Methemoglobinemia is a recognized complication of the use of topical anesthetic sprays. The true scope of the problem or the risk with different topical anesthetic sprays and endoscopic procedures is unknown. METHODS We retrospectively identified all cases of methemoglobinemia that occurred in a university affiliated community hospital from 2001 to 2007. RESULTS Eleven cases of...

Images in cardiovascular medicine. Methemoglobinemia as a rare complication during a transesophageal echocardiogram.

Benzocaine-induced methemoglobinemia.

A case is reported in which a patient developed methemoglobinemia-induced cyanosis while under general anesthesia during surgery for multiple fascial space infections. The cause of methemoglobinemia was 20% benzocaine spray used for local anesthesia before intubation. Acutely developing methemoglobinemia is infrequently encountered in clinical practice. When confronted with cyanosis in the abse...

Poison Control Center Management of Benzocaine Exposures

Benzocaine is a topical anesthetic frequently used in healthcare facilities and in over-the-counter medications in concentrations up to 20%. Benzocaine may induce methemoglobinemia, a condition that impairs the blood’s ability to carry oxygen. The optimal management of exposure to benzocaine remains unclear because serious toxicity is uncommon and may not be dose-related. In 2000, it was estima...